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Creato da: nmdipahozy il 01/09/2010
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Usher and the Peas capture first AMAs of the night

Post n°11 pubblicato il 22 Novembre 2010 da nmdipahozy
 

Usher and the Black Eyed Peas captured the first honors at the American Music Awards on Sunday night, with Usher beating out Alicia Keys and Sade for R&B/Soul album of the year.

"All of my team back in New York City, I'm bringing this home for you," the leather-clad crooner said as he held his trophy high.

The Black Eyed Peas won best pop/rock band, duo or group. While they didn't give a noteworthy speech, frontman will.i.am wore a memorable outfit: A hat and a necklace made out of what appeared to be Legos.

The performance-driven show got off to a colorful and sexy start, courtesy of flaming redhead Rihanna, who performed a medley of songs from her latest album, including the No. 1 hit "What's My Name," wearing a bustier and what seemed like a scarf wrapped around her backside.

Eminem and Lady Antebellum were both up for a show-topping five awards apiece. Other major nominees included Ke$ha and Katy Perry.

A cold Los Angeles night didn't stop the stars from showing a little skin as they arrived for the awards at the Nokia Theatre.

Miley Cyrus walked the red carpet wearing a strapless dress with a flowing train. Avril Lavigne rocked in a mini animal-print dress.

John Legend was more covered up than the ladies, but even he remarked on the cold and windy conditions. Still, he said he expected a "pop music explosion" during the show.

___

Editors: Entertainment Writer Derrik L. Lang contributed to this report.

___

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Glaxo has no Genzyme interest, seeks lower R&D risk

Post n°10 pubblicato il 22 Novembre 2010 da nmdipahozy
 

BOSTON (Reuters) – GlaxoSmithKline Plc says it is not interested in making a counterbid for U.S. biotech company Genzyme Corp and that an acquisition of such size would be disruptive to its own research and development.

Glaxo has been cited as one of a number of parties contacted by Genzyme to determine its value as it fends off an $18.5 billion hostile takeover bid from France's Sanofi-AventisSA.

"Those kind of big deals are incredibly destructive to research and development," said Patrick Vallance, senior vice president of medicines discovery and development, who argued that the process can lead to chaos. "There is an argument for maintaining a stable R&D organization."

Speaking on Thursday to reporters in Cambridge, Massachusetts, not far from Genzyme's headquarters, Vallance and other Glaxo executives outlined their own strategy for drug discovery, and said big acquisitions are not part of the plan.

At a time when many large pharmaceuticals companies are struggling to develop new drugs from their internal research operations, Glaxo is experimenting with business models that could hedge its risk of failure.

One is option-based financing, where, instead of buying a company or an asset outright, it gets an option to buy the asset based on its progress in clinical trials. It is a model that is increasingly being adopted by other pharmaceuticals companies and mid-sized specialty drug companies such as Cephalon Inc.

"It allows GSK to 'test drive' the technology," said Rob Aboud, vice president, global operations and strategy development. "If GSK doesn't exercise the option, the biotech company keeps the programs."

The company is also moving away from developing drugs to treat diseases such as depression and schizophrenia where results are hard to predict and most drugs fail. The risk does not diminish even as the products move through late-stage clinical trials, Vallance said.

Instead, the company is focusing more on drugs for rare diseases, where patient populations are well defined, the disease can be accurately diagnosed and regulators are a little more lenient given the lack of treatments on the market.

Benlysta, the lupus drug Glaxo is developing with Human Genome Sciences meets that profile, Vallance said.

"It's exactly the sort of thing we want to be doing."

On Tuesday, an advisory panel to the U.S. Food and Drug Administration recommended that the agency approve Benlysta, which analysts estimate could generate annual sales of up to $5 billion.

MORE LATE-STAGE TRIALS, FEWER FAILURES

Whether the company's strategy is successful in bringing new products to the market remains to be seen, but Vallance said Glaxo is moving more drugs into late-stage clinical trials and is experiencing fewer failures along the way.

"It's early days," he said, "but our late-stage pipeline is very different from four years ago."

Glaxo held its day-long meeting at the headquarters of Sirtris, a company Glaxo bought in 2008 for $720 million. Sirtris achieved renown for its development of resveratrol, a natural enzyme found in red wine that received much publicity for its potential to lengthen life.

That hype moderated and Sirtris's chief executive, George Vlasuk, who joined the company in 2009, said since then the company, which vigorously fights to maintain its independence within Glaxo, has returned to a focus on science.

"We're not interested in longevity, we're interested in making aging a bit more tolerable," he said.

The first indications of whether the company's lead product, SRT2104, has promise, will emerge next year, with the unveiling of results from the first set of clinical trials. But it may be years before a product reaches the market, and there is skepticism among scientists that the drug can work.

Still, Glaxo has bet big on Sirtris and is willing to invest in other partnerships or companies that it believes can produce innovative medicines.

SELF-REPLICATING DISCOVERY

According to Vallance, one of the reasons drugmakers have failed to produce many new drugs, despite the money poured into research and development, is that they have invested in areas that have proven successful historically.

That has lead the discovery process to be "self-replicating," he said.

Glaxo wants to move away from the "industrialized" process of drug development to one in which individual scientific judgment is brought back into a process that has, he said, become increasingly automated.

As a result, the company created 40 Discovery Performance Units focused around specific technology platforms or therapeutic areas - with a staff of eight to 70 people who compete for funding from GlaxoSmithKline.

The idea is for the units to operate with entrepreneurial flair while having access to Glaxo's vast resources that a typical biotech would not have.

"We have a smaller overall pipeline with a higher portion in late-stage development," Vallance said.

(Reporting by Toni Clarke. Editing by Robert MacMillan)

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U.S. says China must press North Korea on uranium program

Post n°9 pubblicato il 22 Novembre 2010 da nmdipahozy
 
Tag: apre

WASHINGTON (Reuters) – North Korea's effort to enrich uranium is typical of its defiance of the United Nations, and major powers including China must put pressure on Pyongyang to abandon its nuclear ambitions, senior U.S. officials said on Sunday.

North Korean officials took a U.S. nuclear scientist, Siegfried Hecker of Stanford University, to a plant at its Yongbyon nuclear complex where he saw hundreds of centrifuges that Pyongyang said were installed and operational.

Washington has believed since 2002 that Pyongyang had such an enrichment program, but the apparent sophistication of its effort could ignite fresh debate over how to deal with North Korea's unpredictable leadership and whether to resume talks aimed at ending its nuclear ambitions.

"The notion that they could develop this is obviously a concern, but I would say fairly consistent with their longstanding willingness to ignore the U.N.," Defense Secretary Robert Gates said.

"North Korea has ignored a number of Security Council resolutions and sanctions. They continually try to export weapons in violation of those resolutions," Gates told reporters in Santa Cruz, Bolivia, where he was attending a conference of American defense ministers.

Admiral Mike Mullen, chairman of the military's Joint Chiefs of Staff, said the disclosure showed that North Korea was a "dangerous country" intent on making nuclear weapons and major powers must work together to put pressure on North Korean leader Kim Jong-il.

"We have to continue to bring pressure on him specifically. Those in the region -- in particular the six-party talk countries, Russia, China, the United States, Japan, and South Korea -- we all have to continue to do that," Mullen told ABC television's "This Week with Christiane Amanpour" talk show.

Asked whether this new facility raised concerns the North was making more nuclear weapons "right now," Mullen told ABC: "This certainly gives that potential real life."

The North Koreans told Hecker they had 2,000 centrifuges in operation, but the U.S. team that visited the country was unable to verify that they were working. Hecker said North Korea claimed the program was aimed at generating electricity.

Gates dismissed the notion the enrichment program might be for energy production, saying North Korea had an ongoing nuclear arms program for some time and probably had a number of nuclear devices.

"I believe they have nuclear weapons, they're clearly developing longer-range missiles, including potentially a mobile ICBM (intercontinental ballistic missile), so all of these programs are of great concern to every nation," he said.

Gates said he had "no idea" what motivated North Korea to reveal the plant at this time, and he declined to discuss U.S. options going forward, saying the incident occurred while he was out of the country and he needed to consult first with other U.S. security and diplomatic officials.

CHINA'S ROLE

By showing off its nuclear hand, analysts say North Korea is seeking to gain leverage in any aid-for-disarmament negotiations in stalled six-way talks with regional powers China, Japan, South Korea, Russia and the United States.

Its nuclear program is seen as a threat to U.S. allies Japan and South Korea, and a proliferation risk given North Korea's long history of selling missile technology abroad.

The top U.S. envoy on North Korea arrived in Seoul late on Sunday to discuss with key Asian nations ways to thwart Pyongyang's nuclear ambitions.

Mullen singled out China -- North Korea's closest ally -- saying Beijing would necessarily have "an awful lot to do with" future attempts to sway Pyongyang.

"We've been engaged with China for an extended period of time with respect to North Korea ... a great part of this, I think, will have to be done through Beijing," he told ABC.

Mullen put the nuclear disclosure in context by pointing to the March sinking of a South Korean warship, which Washington and Seoul blame on Pyongyang. The suspected torpedo attack killed 46 South Korean sailors and stoked tensions on the peninsula.

"All of this is consistent with belligerent behavior -- the kind of instability creation in a part of the world that is very dangerous," Mullen said.

The North's reported nuclear advances come nearly two months after Kim Jong-il started the transition of power to his youngest son, Kim Jong-un. Analysts say he wants to use nuclear muscle to boost his son's credentials with the military.

"And, in fact, I also believe that this has to do with a succession plan for his son," Mullen said.

(Additional reporting by Arshad Mohammed in Washington, David Alexander in Santa Cruz, and Jeremy Laurence in Seoul; Editing by Stacey Joyce)

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Palestinians: 1 killed in Gaza car blast

Post n°8 pubblicato il 17 Novembre 2010 da nmdipahozy
 
Tag: querela

GAZA CITY, Gaza Strip – An explosion ripped through a car in Gaza City on Wednesday, killing one person and wounding four others, officials with the ruling Hamas movement said.

Hamas medical official Adham Abu Salmia said officials were still trying to determine the cause of the blast and the identities of the victims.

But he said unmanned Israeli aircraft had been flying overhead at the time, and radio stations affiliated with both Hamas and the Islamic Jihad militant groups claimed there had been an Israeli airstrike.

The Israeli military did not immediately comment.

Israel has killed dozens of wanted Palestinian militants — and a similar number of bystanders — in airstrikes over the years. But Israel has greatly scaled back its operations since a fierce military offensive in early 2009.

Early this month, an Israeli airstrike killed a leader of the Army of Islam, a shadowy militant group that is inspired by al-Qaida.

Hamas controls the Gaza Strip, while the rival Palestinian Authority governs the West Bank.

Wednesday's violence came as Israel and the United States were in a standoff over the terms of a Washington-proposed settlement construction moratorium in the West Bank.

The U.S. hopes that by halting Israeli settlement construction, it can bring the West Bank government back to peace talks. Negotiations broke down in late September, just weeks after they were launched, with the expiration of an earlier Israeli settlement slowdown.

The U.S. wants Israel to halt settlement construction for an additional 90 days. In exchange, it has offered key military and diplomatic incentives to Israel.

But Israel is seeking further assurances that it will not be required to extend the freeze any further, and that east Jerusalem — the section of the holy city claimed by the Palestinians — not be subject to building restrictions.

An Israeli official said Wednesday those terms have not been finalized.

U.S. envoy David Hale met with Palestinian officials in the West Bank on Wednesday to discuss the emerging deal.

Palestinian negotiator Saeb Erekat said the Palestinians would not have any comment until a deal is officially worked out.

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UK Retailer Pulls Toshiba Folio 100 Tablet From Stores

Post n°7 pubblicato il 17 Novembre 2010 da nmdipahozy
 
Tag: figc

U.K.-based consumer electronics vendor Dixon's Retail on Monday confirmed that is has pulled Toshiba's Folio 100 tablet from store shelves because of high return rates.

The Folio tablet, which started shipping to consumers earlier this month, has been pulled from the shelves of retail stores owned by Dixon's such as PC World. The tablet .

"We have taken the Toshiba Folio off sale temporarily as we have had a high level of returns and we do not want to give our customers a bad experience of what is actually a very good product," wrote Simon Branney, a Dixon's spokesman, in an e-mail.

"We are working with Toshiba to identify what the issue is and hope to have a resolution very soon," Branney wrote.

When contacted, Toshiba Europe could not elaborate on the issue resulting in heavy return rates.

"Toshiba is aware of reports regarding customer returns of Folio 100 in the U.K. We are currently working&#160;with Dixon's Retail to evaluate the situation," said Gianluca Dianese, head of strategic marketing for the Europe and Middle East region at Toshiba Europe, in an e-mail.

Toshiba started shipping the Folio 100 tablet in Europe earlier this month. The Folio includes a 10.1-inch screen, and runs Google's Android 2.2 OS. It is powered by Nvidia's Tegra chip, which includes a dual-core Arm processor and a graphics core capable of playing 1080p high-definition video. Depending on the features, Toshiba said the device is priced between &#8364;399 and &#8364;529 (US$546 and $723).

This is a big setback for Toshiba, which is pushing the Folio 100 as an iPad competitor as it tries to grab share in the fast-growing tablet market. Research firm Gartner has projected tablet shipments to reach 58.4 million in 2011.

The Folio 100 tablet will not ship to the U.S., a spokesman for Toshiba America said in an e-mail on Monday. The company is planning different form factors for the U.S. market, the spokesman said, without providing further details.

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