DelveInsight’s “Pancreatic Cancer Pipeline Insight, 2025,” report delivers extensive analysis on over 170 companies and more than 200 pipeline drugs in the Pancreatic Cancer treatment arena. It includes thorough profiles of Pancreatic Cancer pipeline drugs, encompassing clinical and nonclinical development stages. Additionally, it evaluates Pancreatic Cancer Pipeline therapeutics by product category, development phase, administration method, and molecular structure. It also points out discontinued pipeline products in this domain.
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Key Takeaways from the Pancreatic Cancer Pipeline Report
- On August 28, 2025, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins disclosed a Phase 2 trial of NC410 and FOLFIRINOX combined with Nivolumab with or without Ipilimumab in treatment-naive, metastatic Pancreatic Cancer patients.
- On August 27, 2025, Joseph J. Cullen conducted a study incorporating 75 grams of ascorbate (vitamin C, referred to as pharmacological ascorbate due to the high dose) into standard therapy. The ascorbate is delivered intravenously via an arm vein.
- On August 26, 2025, Ruijin Hospital organized an open, single-center, exploratory clinical trial to assess the safety and effectiveness of HRS-4642 combined with gemcitabine and albumin-bound paclitaxel for neoadjuvant and adjuvant therapy in Pancreatic Cancer.
- DelveInsight’s Pancreatic Cancer pipeline report illustrates a vibrant arena with over 170 active contributors developing more than 200 pipeline treatments for Pancreatic Cancer care.
- The prominent Pancreatic Cancer Companies include Fibrogen, AB Science, Eleison Pharmaceuticals LLC, Janssen Pharmaceuticals, CARsgen Therapeutics, Arcus Biosciences, Inc., Chia Tai Tianqing Pharmaceutical Group, Innovent Biologics, Amgen, Biomea Fusion, Prestige Biopharma Limited, Bristol-Myers Squibb, GlaxoSmithKline, Incyte Corporation, Helix BioPharma, Genentech, Inc., ENB Therapeutics, Carrick Therapeutics, Avenge Bio, DEKA Biosciences, Keymed Biosciences, Pfizer, Redx Pharma Plc, and AIM ImmunoTech Inc., and others.
- Promising Pancreatic Cancer Pipeline Therapies include Gemcitabine plus TS-1, Gemcitabine, FOLFOX, Nanoplatin (NC-6004), and Gemcitabine, and others.
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Pancreatic Cancer Emerging Drugs Profile
- Pamrevlumab: FibroGen Pamrevlumab is a potential pioneering antibody developed by FibroGen that blocks the function of connective tissue growth factor (CTGF), a key player in fibrotic and proliferative conditions marked by persistent and excessive scarring that can cause organ dysfunction and failure. The U.S. Food and Drug Administration has awarded Orphan Drug Designation and Fast Track status to Pamrevlumab for Pancreatic Cancer patients. It is currently in Phase III clinical trials for Pancreatic Cancer.
- Masitinib: AB Science Masitinib (AB-1010) is an experimental drug for metastatic Pancreatic Cancer. The candidate is taken orally. It competes at the ATP-binding site. It inhibits wild-type forms of c-KIT, Fyn, Lyn tyrosine kinase, and platelet-derived growth factor receptor alpha and beta. Masitinib is a selective inhibitor targeting KIT. It is under Phase III evaluation.
- Glufosfamide: Eleison Pharmaceuticals LLC. Glufosfamide links the active component of ifosfamide, from the alkylator class of chemotherapies, with a glucose molecule. Due to its glucose part and tumors’ higher glucose demand, glufosfamide may preferentially enter tumors over most healthy tissues. Inside cells, the glucose-alkylator bond breaks to release the active agent. The drug is in Phase III trials for Pancreatic Cancer.
- Quemliclustat: Arcus Biosciences, Inc. Quemliclustat is a potent and selective small molecule from Arcus Biosciences. It inhibits CD73, preventing adenosine production. Reducing adenosine restores immune function. The candidate is given intravenously and orally. It is in Phase III clinical trials.
- CT041: CARsgen Therapeutics CT041 is a potential first-in-class autologous chimeric antigen receptor CAR T-cell candidate targeting CLDN18.2 protein. CT041 addresses CLDN18.2 positive solid tumors, focusing on Pancreatic Cancer. The candidate is in Phase II.
- DK210: DEKA Biosciences DK210 (EGFR) is the initial experimental therapeutic from Deka’s platform, merging full-strength IL-2 and high-affinity IL-10 cytokines. While IL-2 can be toxic, pairing with IL-10 reduces toxicity and boosts potency, offering a more tolerable and effective option. It is the first in Deka’s DiakinesTM platform, which links cytokines to a single chain variable fragment (scFv) targeting system for precise tissue delivery. The scFv framework also enhances efficacy, safety, and production. The candidate is in Phase I for Pancreatic Cancer.
- CT7001: Carrick Therapeutics Samuraciclib is the most advanced CDK7 inhibitor in clinical development. Blocking CDK7 is a promising strategy as it controls transcription of cancer genes, drives unchecked cell division, and fosters resistance to hormone therapy. Samuraciclib has shown a good safety profile and promising results in early trials. Beyond breast cancer, it has potential in prostate, Pancreatic, ovarian, and colorectal cancers. Samuraciclib received Fast Track designation from the U.S. Food and Drug Administration (FDA) for combination with fulvestrant in CDK4/6i resistant HR+, HER2- advanced breast cancer. Carrick partners with Roche, Menarini Group, and Arvinas/Pfizer to test samuraciclib with Roche’s oral SERD giredestrant, Menarini’s oral SERD elacestrant, and Arvinas/Pfizer’s PROTAC ER degrader vepdegestrant (ARV-471) in late-stage CDK4/6i resistant HR+, HER2- metastatic breast cancer. The drug is in preclinical development for Pancreatic Cancer.
The Pancreatic Cancer Pipeline report provides insights into
- The report furnishes comprehensive details on organizations advancing therapies for Pancreatic Cancer, including the total treatments each company is developing.
- It examines various therapeutic candidates categorized into initial, intermediate, and advanced development stages for Pancreatic Cancer management.
- Pancreatic Cancer Companies are engaged in precision therapeutics with ongoing and paused (inactive or halted) initiatives.
- Pancreatic Cancer Drugs in progress, sorted by development phase, delivery route, target receptor, standalone or combined therapy, unique action mechanisms, and molecular category.
- Comprehensive review of partnerships (corporate alliances and academic collaborations), licensing deals, and funding information to drive future growth in the Pancreatic Cancer market.
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Pancreatic Cancer Companies Fibrogen, AB Science, Eleison Pharmaceuticals LLC, Janssen Pharmaceuticals, CARsgen Therapeutics, Arcus Biosciences, Inc., Chia Tai Tianqing Pharmaceutical Group, Innovent Biologics, Amgen, Biomea Fusion, Prestige Biopharma Limited, Bristol-Myers Squibb, GlaxoSmithKline, Incyte Corporation, Helix BioPharma, Genentech, Inc., ENB Therapeutics, Carrick Therapeutics, Avenge Bio, DEKA Biosciences, Keymed Biosciences, Pfizer, Redx Pharma Plc, and AIM ImmunoTech Inc., and others
Pancreatic Cancer pipeline report assesses the therapeutic potential of pipeline drugs by Route of Administration
- Oral
- Intravenous
- Subcutaneous
- Parenteral
- Topical
Pancreatic Cancer Products have been categorized under various Molecule types such as
- Recombinant fusion proteins
- Small molecule
- Monoclonal antibody
- Peptide
- Polymer
- Gene therapy
Reveal the future of Pancreatic Cancer Treatment. Learn about emerging drugs, pipeline advancements, and key companies with DelveInsight’s expert analysis @ Pancreatic Cancer Market Drivers and Barriers
Scope of the Pancreatic Cancer Pipeline Report
- Coverage- Global
- Pancreatic Cancer Companies- Fibrogen, AB Science, Eleison Pharmaceuticals LLC, Janssen Pharmaceuticals, CARsgen Therapeutics, Arcus Biosciences, Inc., Chia Tai Tianqing Pharmaceutical Group, Innovent Biologics, Amgen, Biomea Fusion, Prestige Biopharma Limited, Bristol-Myers Squibb, GlaxoSmithKline, Incyte Corporation, Helix BioPharma, Genentech, Inc., ENB Therapeutics, Carrick Therapeutics, Avenge Bio, DEKA Biosciences, Keymed Biosciences, Pfizer, Redx Pharma Plc, and AIM ImmunoTech Inc., and others.
- Pancreatic Cancer Pipeline Therapies- Gemcitabine plus TS-1, Gemcitabine, FOLFOX, Nanoplatin (NC-6004) and Gemcitabine, and others.
- Pancreatic Cancer Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
- Pancreatic Cancer Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
Which companies are leading the race in Pancreatic Cancer drug development? Find out in DelveInsight’s exclusive Pancreatic Cancer Pipeline Report-access it now! @ Pancreatic Cancer Emerging Drugs and Major Companies
Table of Contents
- Introduction
- Executive Summary
- Pancreatic Cancer: Overview
- Pipeline Therapeutics
- Therapeutic Assessment
- Pancreatic Cancer – DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Pamrevlumab: FibroGen
- Drug profiles in the detailed report…..
- Mid-Stage Products (Phase II)
- CT041: CARsgen Therapeutics
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I/II)
- DK210: DEKA Biosciences
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Drug: Company Name
- Drug profiles in the detailed report…..
- Inactive Products
- Pancreatic Cancer Key Companies
- Pancreatic Cancer Key Products
- Pancreatic Cancer- Unmet Needs
- Pancreatic Cancer- Market Drivers and Barriers
- Pancreatic Cancer- Future Perspectives and Conclusion
- Pancreatic Cancer Analyst Views
- Pancreatic Cancer Key Companies
- Appendix
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