DelveInsight’s “Severe Hypertriglyceridemia Pipeline Insight, 2026” report delivers in-depth analysis of over 8 companies and 10+ pipeline drugs in the Severe Hypertriglyceridemia (SHTG) landscape. The report profiles drugs across clinical and preclinical stages, evaluates therapeutics by product type, development phase, administration route, and molecule type, and includes details on inactive pipeline candidates.
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Key Highlights from the Severe Hypertriglyceridemia Pipeline Report
- March 30, 2026: Regeneron Pharmaceuticals launched a trial for experimental mibavademab in GLD patients stable on metreleptin for ≥6 months (no dose change in the last 3 months).
- March 24, 2026: Arrowhead Pharmaceuticals started a Phase 2b trial assessing ARO-APOC3’s efficacy and safety in adults with Severe Hypertriglyceridemia.
- March 20, 2026: Eli Lilly and Company initiated a Phase 2 study evaluating solbinsiran’s ability to lower triglycerides and lipids vs. placebo via two subcutaneous doses in SHTG patients.
- The pipeline features 8+ key players developing 10+ therapies for SHTG.
- Leading Companies: Arrowhead Pharmaceuticals, 89bio Inc., Zhejiang Doer Biologics Co., Ltd., OrsoBio Inc., Onconic Therapeutics, Mammoth Biosciences Inc., and more.
- Key Pipeline Therapies: Solbinsiran, Plozasiran Injection, Olezarsen, DR10624, ARO-APOC3, Pegozafermin, Omefas, K-877, Fenofibrate, and others.
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Severe Hypertriglyceridemia: Disease Overview
Severe Hypertriglyceridemia (HTG) involves markedly high blood triglyceride levels, elevating risks of cardiovascular disease (CVD) and pancreatitis. Statins effectively manage LDL-C and ASCVD outcomes, but residual CVD risk persists, especially in mild-to-moderate HTG cases. Direct evidence linking HTG treatment to reduced CVD risk remains limited. Novel options like omega-3s, fibrates, and agents targeting APOC3 or ANGPTL3 show promise. Factors such as genetics, metabolic syndrome, and uncontrolled diabetes drive elevations. Prompt diagnosis and personalized therapy are critical to mitigate pancreatitis and long-term CVD risks.
Emerging Drugs in the Severe Hypertriglyceridemia Pipeline
- Plozasiran (Arrowhead Pharmaceuticals)
A pioneering RNAi therapeutic targeting APOC3 production in triglyceride-rich lipoproteins (TRLs). By inhibiting TRL breakdown and remnant uptake, it aims to normalize triglycerides. Currently in Phase III for Severe Hypertriglyceridemia. - Pegozafermin (89bio, Inc.)
An engineered FGF21 analog using glycoPEGylation for extended half-life, addressing metabolic drivers of liver and cardiometabolic conditions like SHTG. It regulates energy, glucose, and lipids. In Phase III development. - DR10624 (Zhejiang Doer Biologics Co., Ltd.)
A novel tri-agonist (FGF21R, GLP-1R, GCGR) via MultipleBody platform, showing strong preclinical results in weight loss, triglyceride reduction, lipid normalization, and liver health. In Phase II for Severe Hypertriglyceridemia.
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Key Severe Hypertriglyceridemia Companies
Arrowhead Pharmaceuticals, 89bio Inc., Zhejiang Doer Biologics Co., Ltd., OrsoBio Inc., Onconic Therapeutics, Mammoth Biosciences Inc., and others.
The report covers:
- Company-specific therapy portfolios for SHTG.
- Candidates by early-, mid-, and late-stage development.
- Active/inactive projects.
- Drugs by stage, route, target, mono/combo therapy, mechanism, and molecule type.
- Collaborations, licensing, and funding insights.
Therapeutic Assessment by Route of Administration (ROA)
- Inhalation
- Inhalation/Intravenous/Oral
- Intranasal
- Intravenous
- Intravenous/Subcutaneous
- NA
- Oral
- Oral/Intranasal/Subcutaneous
- Parenteral
- Subcutaneous
Molecule Types
- Antibody
- Antisense oligonucleotides
- Immunotherapy
- Monoclonal antibody
- Peptides
- Protein
- Recombinant protein
- Small molecule
- Stem Cell
- Vaccine
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Scope of the Severe Hypertriglyceridemia Pipeline Report
- Coverage: Global
- Companies: Arrowhead Pharmaceuticals, 89bio Inc., Zhejiang Doer Biologics Co., Ltd., OrsoBio Inc., Onconic Therapeutics, Mammoth Biosciences Inc., others.
- Therapies: Solbinsiran, Plozasiran Injection, Olezarsen, DR10624, ARO-APOC3, Pegozafermin, Omefas, K-877, Fenofibrate, others.
- Assessment by Product Type: Mono, Combination, Mono/Combination
- Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
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Table of Contents
* Introduction
* Executive Summary
* Severe Hypertriglyceridemia Overview
* Pipeline Therapeutics
* Therapeutics Assessment
* Severe Hypertriglyceridemia – DelveInsight’s Analytical Perspective
* Late Stage Products (Phase III)
* Plozasiran: Arrowhead Pharmaceuticals
* Mid Stage Products (Phase II)
* DR10624: Zhejiang Doer Biologics Co., Ltd.
* Early Stage Products (Phase I)
* Preclinical and Discovery Stage Products
* Inactive Products
* Severe Hypertriglyceridemia Key Companies
* Severe Hypertriglyceridemia Key Products
* Severe Hypertriglyceridemia- Unmet Needs
* Severe Hypertriglyceridemia- Market Drivers and Barriers
* Severe Hypertriglyceridemia- Future Perspectives and Conclusion
* Severe Hypertriglyceridemia Analyst Views
* Severe Hypertriglyceridemia Key Companies
* Appendix
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