ESMO Virtual Meeting 2020: Report by Xagena
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Advanced urothelial carcinoma: Ibrutinib in combination with Paclitaxel has activity – Final analysis of a phase Ib/II study
Ibrutinib ( Imbruvica ), a once-daily Bruton’s tyrosine kinase ( BTK ) inhibitor approved for various B-cell malignancies, also inhibits other kinases, such as ITK and ETK ( Wang Clin Cancer Res 2018 …
JASPER: Efficacy and safety of first-line Niraparib plus Pembrolizumab in patients with advanced non-small cell lung cancer
Preclinical evidence has suggested that Niraparib ( Zejula ), a poly (ADP-ribose) polymerase inhibitor, may synergise with PD-1 inhibitors. Pembrolizumab ( Keytruda ) is a PD-1 inhibitor approved a …
Capmatinib in patients with METex14-mutated advanced non-small cell lung cancer who received prior immunotherapy: GEOMETRY mono-1 study
MET exon 14 skipping mutations ( METex14 ) are seen in 3-4% of patients with non-small cell lung cancer ( METex14 NSCLC ) and are associated with poor outcomes. In the phase 2 GEOMETRY mono-1 stud …
Apalutamide vs placebo in patients with non-metastatic castration-resistant prostate cancer receiving androgen deprivation therapy: health-related quality of life at final analysis of the SPARTAN study
The phase III SPARTAN study evaluated Apalutamide ( Erleada ) vs Placebo in patients with non-metastatic castration-resistant prostate cancer ( nmCRPC ) who had prostate-specific antigen doubling time …
Efficacy and safety of Pembrolizumab plus chemotherapy to Pembrolizumab monotherapy: a consecutive analysis of NSCLC patients with high PD-L1 expression
There has been an only indirect comparison between Pembrolizumab ( Keytruda ) and Pembrolizumab plus chemotherapy in patients with non-small cell lung cancer ( NSCLC ) and high programmed death-ligand …
Cabozantinib in combination with Atezolizumab in non-clear cell renal cell carcinoma – Results from cohort 10 of the COSMIC-021 study
Non-clear cell renal cell carcinoma ( nccRCC ) encompasses a heterogenous group of histologies comprising approximately 25% of all renal cell carcinoma ( RCC ) diagnoses with worse outcomes than clear …